Sangiah S, Gomez M V, Domino E F
Biol Psychiatry. 1979 Dec;14(6):925-36.
14C-DMT accumulates in rat brain cortical slices incubated at 37 C. This process has many of the properties of an active uptake mechanism. It is temperature-sensitive, sodium-dependent, saturable, and is inhibited by metabolic inhibitors. Tryptamine derivatives were more effective than the catecholamines in competing for 14C-DMT accumulation. A number of psychotropic drugs were inhibitors of 14C-DMT accumulation. In general, irrespective of pharmacologic class, the tertiary amines were more potent than the secondary or primary amines, although there were some exceptions. Most of the accumulated 14C-DMT was associated with the cytoplasmic fraction. Of the portion associated with the crude mitochondrial fraction, 54.4% was associated with nerve-ending fraction.
14C - DMT在37℃孵育的大鼠脑皮质切片中蓄积。该过程具有主动摄取机制的许多特性。它对温度敏感、依赖钠、可饱和，且受代谢抑制剂抑制。色胺衍生物在竞争14C - DMT蓄积方面比儿茶酚胺更有效。许多精神药物是14C - DMT蓄积的抑制剂。一般来说，不论药理类别如何，叔胺比仲胺或伯胺更有效，不过也有一些例外。大部分蓄积的14C - DMT与细胞质部分相关。在与粗线粒体部分相关的部分中，54.4%与神经末梢部分相关。
