Morinan A, Collier J G
Psychopharmacology (Berl). 1981;75(2):179-83. doi: 10.1007/BF00432184.
Mice pretreated with the monoamine oxidase inhibitor pargyline showed a dose-dependent increase in hyperactivity for up to 2 h following injections of N,N-dimethyltryptamine (DMT: 0.5-8.0 mg/kg). Hyperactivity was related to a linear increase in whole brain concentrations of DMT as measured by a new sensitive gas chromatographic assay. The duration of this behaviour paralleled the concentration of DMT in the brain from 15-120 min. However, at 15 min, there was no significant difference in brain DMT concentrations between mice receiving pargyline and those given distilled water at the two dose levels of DMT studied (2.0 and 8.0 mg/kg). Pre-treatment with the microsomal enzyme inhibitor SKF-525A, alone or in combination with pargyline, had no effect on the DMT-induced behaviour or on the brain levels of DMT.
用单胺氧化酶抑制剂帕吉林预处理的小鼠，在注射N，N - 二甲基色胺（DMT：0.5 - 8.0毫克/千克）后长达2小时内，活动亢进呈剂量依赖性增加。通过一种新的灵敏气相色谱分析法测定，活动亢进与全脑DMT浓度的线性增加有关。这种行为的持续时间与15至120分钟内大脑中DMT的浓度平行。然而，在15分钟时，在所研究的两个DMT剂量水平（2.0和8.0毫克/千克）下，接受帕吉林的小鼠与给予蒸馏水的小鼠之间，脑DMT浓度没有显著差异。用微粒体酶抑制剂SKF - 525A单独或与帕吉林联合预处理，对DMT诱导的行为或脑DMT水平均无影响。
