Belal Amer Ashaab, Bourricaudy Rafael Aldaya, Saba Zahra, Alquadan Kawther F, Kazory Amir, Santos Alfonso H
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL 32610, United States.
College of Medicine, University of Florida, Gainesville, FL 32610, United States.
World J Transplant. 2026 Mar 18;16(1):114233. doi: 10.5500/wjt.v16.i1.114233.
With advances in solid organ transplantation, the option of combined kidney with other solid organ transplantation is an enticing option for patients with advanced kidney disease and concomitant other solid organ failure. Kidney allograft dysfunction is well known to be associated with increased adverse outcomes post solitary kidney transplant however, outcomes for patients and the kidney allograft are somewhat understudied in the setting of kidney transplantation when combined with other solid organ transplantation such as in a simultaneous liver-kidney transplant. We will provide an overview of the current literature available on kidney allograft clinical outcome measures in combined solid organ transplant recipients such as delayed kidney allograft function, kidney allograft rejection, kidney allograft and patient survival metrics and how they compare to patients with kidney transplants alone. Worse kidney allograft survival outcomes were noted in most combined other organ with kidney transplantation (liver-kidney, heart-kidney, and lung-kidney) due to comorbidities attributed to non-renal organ dysfunction whereas improved kidney allograft survival outcomes were noted for pancreas-kidney transplantation.
随着实体器官移植技术的进步，对于患有晚期肾病并伴有其他实体器官衰竭的患者而言，肾联合其他实体器官移植是一个诱人的选择。众所周知，孤立肾移植术后同种异体肾移植功能障碍与不良预后增加有关，然而，在肾移植与其他实体器官移植联合进行（如肝肾同期移植）的情况下，患者及同种异体肾移植的预后在一定程度上尚未得到充分研究。我们将概述目前关于联合实体器官移植受者同种异体肾移植临床结局指标的文献，如移植肾延迟功能恢复、同种异体肾移植排斥反应、同种异体肾移植及患者生存指标，以及它们与单纯肾移植患者的比较情况。在大多数肾联合其他器官移植（肝肾、心肾和肺肾移植）中，由于非肾器官功能障碍导致的合并症，同种异体肾移植存活结局较差，而胰肾移植的同种异体肾移植存活结局则有所改善。
