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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Krnjević K, Puil E, Werman R

J Physiol. 1978 Feb;275:225-39. doi: 10.1113/jphysiol.1978.sp012187.

Extracellular iontophoretic applications of DNP lead to an increase in the membrane conductance of cat spinal motoneurones, manifested by a rise in input conductance, a slower rate of rise and fall of action potentials, and occlusion of the afterhyperpolarization. 2. There is also some hyperpolarization, but the reversal potential for the action of DNP is only about 12 mV more negative than the resting potential. 3. These effect of DNP can be abolished or significantly reduced by intracellular injections of EGTA. On the other hand, DNP can partly reverse the decreased conductance and the depression of the slow afterhyperpolarization caused by EGTA. 4. Intracellular injections of DNP also induce a rise in input conductance; when repeated, they tend to have a depolarizing effect, mainly irreversible. 5. It is concluded that DNP acts principally inside the motoneurone, by liberating bound internal Ca, the free Ca ions then raising membrane conductance, especially GK.

二硝基酚（DNP）的细胞外离子导入应用会导致猫脊髓运动神经元的膜电导增加，表现为输入电导升高、动作电位的上升和下降速率减慢以及后超极化的抵消。2. 也会有一些超极化现象，但DNP作用的反转电位仅比静息电位负约12毫伏。3. 通过细胞内注射乙二醇双四乙酸（EGTA），DNP的这些效应可以被消除或显著降低。另一方面，DNP可以部分逆转由EGTA引起的电导降低和慢后超极化的抑制。4. 细胞内注射DNP也会导致输入电导升高；重复注射时，它们往往具有去极化作用，主要是不可逆的。5. 得出的结论是，DNP主要在运动神经元内部起作用，通过释放结合的内部钙，游离的钙离子随后增加膜电导，尤其是钾电导（GK）。

Krnjević K, Puil E, Werman R

J Physiol. 1978 Feb;275:225-39. doi: 10.1113/jphysiol.1978.sp012187.

Extracellular iontophoretic applications of DNP lead to an increase in the membrane conductance of cat spinal motoneurones, manifested by a rise in input conductance, a slower rate of rise and fall of action potentials, and occlusion of the afterhyperpolarization. 2. There is also some hyperpolarization, but the reversal potential for the action of DNP is only about 12 mV more negative than the resting potential. 3. These effect of DNP can be abolished or significantly reduced by intracellular injections of EGTA. On the other hand, DNP can partly reverse the decreased conductance and the depression of the slow afterhyperpolarization caused by EGTA. 4. Intracellular injections of DNP also induce a rise in input conductance; when repeated, they tend to have a depolarizing effect, mainly irreversible. 5. It is concluded that DNP acts principally inside the motoneurone, by liberating bound internal Ca, the free Ca ions then raising membrane conductance, especially GK.

二硝基酚（DNP）的细胞外离子导入应用会导致猫脊髓运动神经元的膜电导增加，表现为输入电导升高、动作电位的上升和下降速率减慢以及后超极化的抵消。2. 也会有一些超极化现象，但DNP作用的反转电位仅比静息电位负约12毫伏。3. 通过细胞内注射乙二醇双四乙酸（EGTA），DNP的这些效应可以被消除或显著降低。另一方面，DNP可以部分逆转由EGTA引起的电导降低和慢后超极化的抑制。4. 细胞内注射DNP也会导致输入电导升高；重复注射时，它们往往具有去极化作用，主要是不可逆的。5. 得出的结论是，DNP主要在运动神经元内部起作用，通过释放结合的内部钙，游离的钙离子随后增加膜电导，尤其是钾电导（GK）。