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嗜铬细胞瘤的麻醉管理

Anaesthetic management of phaeochromocytoma.

作者信息

Pratilas V, Pratila M G

出版信息

Can Anaesth Soc J. 1979 Jul;26(4):253-9. doi: 10.1007/BF03006283.

Abstract

The incidence, mortality, physiology, clinical findings and diagnosis of phaeochromocytoma are reviewed. Treatment, after adequate medical stabilization, must be surgical because of the high incidence of malignancy. Alpha-adrenergic receptor blockade and beta-adrenergic receptor blockade in the preoperative period was discussed. Anaesthetic management of patients with phaeochromocytoma requires close monitoring. Virtually all inhalational anaesthetic agents have been used in cases of phaeochromocytoma. Recent reports have favored enflurane. The merits of neuroleptanaesthesia and the various muscle relaxants are also discussed. Most authors favour lidocaine over propranolol for management of dysrhythmias during operation. Phentolamine or sodium nitroprusside are used for hypertension during operation. Hypotension is treated by fluid replacement with nor-epinephrine if a vasopressor becomes necessary. Close monitoring is necessary in the postoperative period. Adequate urinary output is of more importance than actual blood pressure levels.

摘要

本文综述了嗜铬细胞瘤的发病率、死亡率、生理学、临床表现及诊断。由于恶性肿瘤发生率高,在充分的医学稳定治疗后,必须进行手术治疗。文中讨论了术前α-肾上腺素能受体阻滞剂和β-肾上腺素能受体阻滞剂的应用。嗜铬细胞瘤患者的麻醉管理需要密切监测。几乎所有吸入性麻醉剂都曾用于嗜铬细胞瘤病例。最近的报告倾向于使用安氟醚。文中还讨论了神经安定麻醉和各种肌肉松弛剂的优点。大多数作者在手术期间处理心律失常时更倾向于使用利多卡因而非普萘洛尔。手术期间高血压用酚妥拉明或硝普钠治疗。如果需要血管升压药,低血压通过补充液体加去甲肾上腺素治疗。术后需要密切监测。充足的尿量比实际血压水平更重要。

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