Schmucki O
Helv Chir Acta. 1979 Aug;46(3):287-90.
The occurrence of hypertensive crises, arrhythmias and hypotensive crises during surgery for pheochromocytoma can be prevented both preoperatively and intraoperatively by adequate alpha-adrenergic blockade and volume replacement. Only in a few cases is additional beta-adrenergic blockade necessary. Preoperatively the author uses phenoxybenzamine (Dibenicyline) as alpha-blockade in a dose of 20-30 mg daily, and propanolol (Inderal) as beta-blockade in a dose of 4 X 20 mg daily, both given orally. Intraoperatively he gives preference to alpha-adrenergic receptor blockers with a short halflife, i.e. phentolamine (Regitin) and lidocaine or pranolol as the beta-adrenergic blocker.
在嗜铬细胞瘤手术期间,通过充分的α-肾上腺素能阻滞和容量补充,可在术前和术中预防高血压危象、心律失常和低血压危象的发生。仅在少数情况下才需要额外的β-肾上腺素能阻滞。术前,作者使用苯苄胺(双苄胺)作为α-阻滞剂,每日剂量为20 - 30毫克,普萘洛尔(心得安)作为β-阻滞剂,每日剂量为4×20毫克,均口服给药。术中他优先选择半衰期短的α-肾上腺素能受体阻滞剂,即酚妥拉明(利其丁),以及利多卡因或普萘洛尔作为β-肾上腺素能阻滞剂。