通过向大鼠单次注射重氮丝氨酸诱导肝细胞改变灶。
Induction of foci of altered hepatocytes by a single injection of azaserine to rats.
作者信息
Takahashi S, Katyal S L, Lombardi B, Shinozuka H
出版信息
Cancer Lett. 1979 Sep;7(5):265-72. doi: 10.1016/s0304-3835(79)80053-1.
The induction of foci of altered, gamma-glutamyltranspeptidase (GGT)-positive hepatocytes by azaserine was investigated. After injection of a single dose of azaserine, many foci developed in male Wistar rats fed a choline-devoid (CD) diet containing acetylaminofluorene (AAF), but only a few in rats fed a choline-supplemented (CS) diet containing AAF. Similar results were obtained in rats fed a plain CD diet or a plain CS diet and injected with a single dose of azaserine after a partial hepatectomy. These findings indicate that azaserine is an effective initiator of liver carcinogenesis in rats, and that a CD diet acts as a strong promoter of the evolution initiated liver cells to foci of altered, GGT-positive hepatocytes.
研究了重氮丝氨酸对改变的γ-谷氨酰转肽酶（GGT）阳性肝细胞灶的诱导作用。给雄性Wistar大鼠注射单剂量重氮丝氨酸后，在喂食含乙酰氨基芴（AAF）的无胆碱（CD）饮食的大鼠中出现了许多病灶，但在喂食含AAF的补充胆碱（CS）饮食的大鼠中仅出现了少数病灶。在喂食普通CD饮食或普通CS饮食并在部分肝切除术后注射单剂量重氮丝氨酸的大鼠中也获得了类似结果。这些发现表明，重氮丝氨酸是大鼠肝癌发生的有效启动剂，并且CD饮食是已启动的肝细胞演变为改变的GGT阳性肝细胞灶的强促进剂。
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