Barnett E V
Calif Med. 1966 Jun;104(6):463-9.
The lupus erythematosus (LE) cell factor is one of a variety of heterogeneous antibodies directed against many nuclear antigens. These antinuclear antibodies are found in a wide variety of clinical disorders. As detected by immunofluorescence techniques, they are so frequently found in association with systemic lupus erythematosus that their absence essentially excludes that diagnosis. It is suggested that in certain situations other than systemic lupus, antinuclear antibodies may be the result of some inflammatory and destructive processes. Antinuclear antibodies may be detected in certain lower animals frequently in association with disease. In lower animals, immunization with nuclear antigens appropriately complexed* to protein carriers consistently results in the induction of antinuclear antibodies. In both man and animals, antinuclear antibodies are often detected without associated disease. Furthermore, antinuclear antibodies are not injurious to intact tissue culture cells. Nonetheless, antigen-antibody complexes consisting of nuclear antigens and antinuclear antibodies may contribute to the propagation of certain diseases, particularly lupus nephritis. The use of antinuclear antibodies as immunochemical tools holds great promise for the better understanding of such nuclear antigens as are found in viruses and in the nuclei of certain malignant cells.
红斑狼疮（LE）细胞因子是多种针对许多核抗原的异质性抗体之一。这些抗核抗体存在于多种临床疾病中。通过免疫荧光技术检测，它们在系统性红斑狼疮中非常常见，以至于它们的缺失基本上可以排除该诊断。有人提出，在系统性红斑狼疮以外的某些情况下，抗核抗体可能是某些炎症和破坏过程的结果。抗核抗体在某些低等动物中经常与疾病相关联而被检测到。在低等动物中，用与蛋白质载体适当复合的核抗原进行免疫接种始终会导致抗核抗体的诱导。在人和动物中，经常在没有相关疾病的情况下检测到抗核抗体。此外，抗核抗体对完整的组织培养细胞没有损害。尽管如此，由核抗原和抗核抗体组成的抗原 - 抗体复合物可能会促进某些疾病的传播，特别是狼疮性肾炎。将抗核抗体用作免疫化学工具对于更好地理解病毒和某些恶性细胞核中发现的此类核抗原具有很大的前景。
