低丙种球蛋白血症中γ球蛋白的异质性有限。
Limited heterogeneity of gamma globulin in hypogammaglobulinemia.
作者信息
Hong R, Good R A
出版信息
Science. 1967 May 26;156(3778):1102-3. doi: 10.1126/science.156.3778.1102.
PMID:4164702
Abstract
When serums of 11 patients with hypogammaglobulinemia were examined by acrylamide-gel electrophoresis, combined with diffusion analysis, for the gamma chain of immunoglobulin G, the electrophoretic distribution of immunoglobulin G differed from that of normal individuals. The differences consisted of limited heterogeneity and bimodal distributions of the proteins at times. Isolated immunoglobulin G from four of the patients showed similar phenomena. The findings indicate a deficient gene population in these patients.
摘要
当采用丙烯酰胺凝胶电泳并结合扩散分析，对11例低丙种球蛋白血症患者的血清进行免疫球蛋白Gγ链检测时，免疫球蛋白G的电泳分布与正常个体不同。差异有时表现为蛋白质的有限异质性和双峰分布。从4例患者中分离出的免疫球蛋白G也显示出类似现象。这些发现表明这些患者存在基因群体缺陷。
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