Kovác G, Vrzgula L
Vet Med (Praha). 1978 Jan;23(1):1-7.
The effects of drugs containing vitamin E for peroral administration (Combinal E), intramuscular injection (Erevit) and parenteral administration of a combined drug containing vitamin E and selenium (Selevit) on vitamin E levels in the ovine blood serum were studied. A uniform dose of 15 mg tocopherol acetate per 1 kg live weight was administered to the experimental animals. The level of vitamin E after the peroral administration of Combinal E was affected to a lesser extent than in swine and calves. The serum was examined before and after saponification to determine the effect of the intramuscular injection of Erevit; it was found out that tocopherol acetate prevailed in the blood serum in the first hours after such a route of administration. The best results were obtained after both subcutaneous and intramuscular administration of Selevit, the levels of free tocopherol showing high values even at the end of the experiments. These results may be made use of in determining effective preventive and therapeutic measures to do away with the white muscle disease in practice.
研究了口服含维生素E的药物（复合维生素E）、肌肉注射（益维特）以及肠胃外注射含维生素E和硒的复合药物（硒维特）对绵羊血清中维生素E水平的影响。给实验动物每1千克活重均匀投喂15毫克醋酸生育酚。与猪和牛犊相比，口服复合维生素E后维生素E水平受影响的程度较小。在皂化前后对血清进行检测，以确定益维特肌肉注射的效果；结果发现，经此给药途径后的最初几个小时内，血清中醋酸生育酚占主导。皮下和肌肉注射硒维特均取得了最佳效果，即使在实验结束时，游离生育酚水平仍显示出较高值。这些结果可用于确定在实践中消除白肌病的有效预防和治疗措施。
