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肾上腺素和去甲肾上腺素对甲状腺外置绵羊激素分泌及甲状腺静脉血流量的影响。

The effect of adrenaline and noradrenaline on hormone secretion and blood flow from the thyroid vein in sheep with exteriorized thyroids.

作者信息

Falconer I R

出版信息

J Physiol. 1967 Feb;188(3):425-34. doi: 10.1113/jphysiol.1967.sp008147.

Abstract
  1. Emotional stimulus to the sheep has previously been shown to cause increased thyroid hormone secretion; the influence of adrenaline and noradrenaline in this process has been investigated.2. Sheep bearing exteriorized thyroid glands on carotid artery-jugular vein loops were used. Thyroid vein blood was collected through a cannula in the jugular vein within the loop, and blood flow was measured by a plethysmographic technique.3. (131)I (50 muc) was injected intramuscularly (I.M.) into the sheep, and 4-7 days later the concentration of total and protein bound (131)I in thyroid vein blood was measured in samples taken every 10 min for 4 hr. Intracarotid injections of 1 mug, I.V. injections of 5 mug, or I.V. infusions at 10 mug/min for 10 min, of adrenaline or noradrenaline were administered 1.5 hr after commencement of sampling. Blood flow from the thyroid was measured in similar experiments.4. No significant changes in thyroid hormone secretion could be attributed to adrenaline or noradrenaline, and it was concluded that circulating catecholamines do not influence the release of thyroid hormone observed after brief emotional stimulus in the sheep.
摘要
  1. 先前已表明,对绵羊的情绪刺激会导致甲状腺激素分泌增加;已对肾上腺素和去甲肾上腺素在此过程中的影响进行了研究。

  2. 使用在颈动脉 - 颈静脉环上带有外置甲状腺的绵羊。通过环内颈静脉中的插管收集甲状腺静脉血,并采用体积描记技术测量血流量。

  3. 将(131)I(50 微居里)肌肉注射到绵羊体内,4 - 7 天后,在 4 小时内每隔 10 分钟采集一次样本,测量甲状腺静脉血中总(131)I 和蛋白结合(131)I 的浓度。在采样开始 1.5 小时后,进行颈动脉内注射 1 微克、静脉注射 5 微克或静脉输注 10 微克/分钟持续 10 分钟的肾上腺素或去甲肾上腺素。在类似实验中测量甲状腺的血流量。

  4. 甲状腺激素分泌的显著变化不能归因于肾上腺素或去甲肾上腺素,得出的结论是,循环中的儿茶酚胺不会影响绵羊在短暂情绪刺激后观察到的甲状腺激素释放。

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ADRENAL MEDULLARY AND THYROID RELATIONSHIPS.肾上腺髓质与甲状腺的关系。
Physiol Rev. 1964 Apr;44:161-85. doi: 10.1152/physrev.1964.44.2.161.

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