Rasmussen S, Døssing M, Walbom-Jørgensen S
Acta Med Scand. 1978;203(3):237-9. doi: 10.1111/j.0954-6820.1978.tb14863.x.
A 21-year old man died of an extensive anteroseptal myocardial infarction 16 months after receiving megavoltage radiotherapy to a mantle field for Hodgkin's disease stage PS IA confined to the midcervical lymph nodes on the left side of the neck. Post mortem findings revealed severe atherosclerotic changes in the coronary arteries. This case and a review of the literature suggest that irradiation to the heart may induce or accelerate atherosclerosis of the epicardial vessels. This should be taken into consideration when starting prophylactic irradiation to the mantle field in patients with Hodgkin's disease stage IA without obvious involvement of the mediastinun. Histologic examination of the heart and coronary vessels should be performed in any fatal case after megavoltage therapy involving the heart.
一名21岁男性在接受颈部左侧中颈淋巴结局限的霍奇金病PS IA期斗篷野兆伏放疗16个月后，死于广泛的前间隔心肌梗死。尸检结果显示冠状动脉有严重的动脉粥样硬化改变。该病例及文献综述提示，心脏照射可能诱发或加速心外膜血管的动脉粥样硬化。对于无明显纵隔受累的霍奇金病IA期患者开始斗篷野预防性照射时应考虑到这一点。在涉及心脏的兆伏治疗后的任何致命病例中，均应对心脏和冠状动脉进行组织学检查。
