Jones W I, Klein F, Lincoln R E, Walker J S, Mahlandt B G, Dobbs J P
J Bacteriol. 1967 Sep;94(3):609-14. doi: 10.1128/jb.94.3.609-614.1967.
Quantitative measurements of mean time to death, percentage of survivors, and viable cell populations in the whole body were employed to determine the effects of penicillin, dihydrostreptomycin, chlortetracycline, oxytetracycline, chloramphenicol, and antiserum on the course of anthrax infection in mice. By all parameters tested, penicillin and dihydrostreptomycin were most effective in the treatment of the disease. Therapy initiated in the later stages of the disease was more effective than that initiated in the earlier stages. Quantitative studies indicated that it was more difficult to eliminate organisms from the kidney than from any other organ or tissue. These measurements for the evaluation of antibiotic therapy are suggested for the study of other bacterial diseases.
采用对平均死亡时间、存活百分比以及全身活细胞数量进行定量测量的方法，来确定青霉素、双氢链霉素、金霉素、土霉素、氯霉素和抗血清对小鼠炭疽感染病程的影响。在所测试的所有参数方面，青霉素和双氢链霉素在治疗该疾病方面最为有效。在疾病后期开始的治疗比在早期开始的治疗更有效。定量研究表明，从肾脏中清除病原体比从任何其他器官或组织中清除更困难。建议将这些用于评估抗生素治疗的测量方法应用于其他细菌性疾病的研究。
