蛋白质-热量营养不良时红细胞膜的变化。

Changes in the red blood cell membrane in protein-calorie malnutrition.

作者信息

Brown K H, Suskind R M, Lubin B, Kulapongs P, Leitzmann C, Olson R E

出版信息

Am J Clin Nutr. 1978 Apr;31(4):574-8. doi: 10.1093/ajcn/31.4.574.

DOI:10.1093/ajcn/31.4.574

Abstract

Ten children with protein-calorie malnutrition (five with kwashiorkor, three with marasmus, and two with marasmic-kwashiorkor) were studied at hospital admission and during recovery for evidence of changes in red blood cell lipids, osmotic fragility, and chromium survival. On admission, the children had significantly higher-than-normal red blood cell membrane cholesterol and phospholipid, and an elevated cholesterol:phospholipid ratio. Both red blood cell osmotic fragility and red cell survivals were depressed. These measurements returned to normal limits with recovery.

摘要

对10名蛋白质-热量营养不良的儿童（5名夸希奥科病患儿、3名消瘦症患儿和2名消瘦-夸希奥科病患儿）在入院时和康复期间进行了研究，以寻找红细胞脂质、渗透脆性和铬存活情况变化的证据。入院时，这些儿童的红细胞膜胆固醇和磷脂显著高于正常水平，胆固醇与磷脂的比例升高。红细胞渗透脆性和红细胞存活率均降低。随着康复，这些测量值恢复到正常范围。