Wolff J A, Margolis S, Bujdoso-Wolff K, Matusick E, MacLean W C
Pediatr Res. 1984 Feb;18(2):162-7. doi: 10.1203/00006450-198402000-00010.
Plasma and red cell fatty acids were measured in 44 children with third degree malnutrition: 22 children with marasmus, 11 children with kwashiorkor, and 11 with marasmic kwashiorkor (MK). The presence of edema, dermatosis, hair changes, and hypoalbuminemia were positively correlated with the red cell percentage linoleic acid and negatively correlated with red cell percentage arachidonic acid. Red cell percentage linoleic acid in kwashiorkor was decreased from the control value of 15.3% to 10.9%. In marasmus and MK, there were significantly greater decreases, to 7.7% and 8.0%, respectively. Red cell arachidonic acid in kwashiorkor was significantly (P less than 0.001) decreased to 9.8% (control value of 13.1%) whereas in marasmus there was no significant change. Only one sample, plasma from an infant with marasmus, had any detectable eicosatrienoic acid (20:3,omega 9). Similar changes in fatty acid composition have been reported in infants with acrodermatitis enteropathica, in an infant with biotin deficiency, and in biotin-deficient rats.
对44名重度营养不良儿童的血浆和红细胞脂肪酸进行了测定：其中22名消瘦型营养不良儿童，11名夸希奥科病儿童，11名消瘦 - 夸希奥科病（MK）儿童。水肿、皮肤病、毛发改变和低白蛋白血症的存在与红细胞亚油酸百分比呈正相关，与红细胞花生四烯酸百分比呈负相关。夸希奥科病患儿红细胞亚油酸百分比从对照值的15.3%降至10.9%。在消瘦型营养不良和消瘦 - 夸希奥科病患儿中，下降幅度更大，分别降至7.7%和8.0%。夸希奥科病患儿红细胞花生四烯酸显著（P<0.001）降至9.8%（对照值为13.1%），而消瘦型营养不良患儿则无显著变化。仅1份样本，即1名消瘦型营养不良婴儿的血浆中检测到任何二十碳三烯酸（20:3，ω9）。在患有肠病性肢端皮炎的婴儿、生物素缺乏的婴儿以及生物素缺乏的大鼠中也报道了类似的脂肪酸组成变化。
