抗淋巴细胞球蛋白在同种肾移植中的临床应用。
The clinical use of antilymphocyte globulin in renal homotransplantation.
作者信息
Starzl T E, Marchioro T L, Hutchinson D E, Porter K A, Cerilli G J, Brettschneider L
出版信息
Transplantation. 1967 Jul;5(4):Suppl:1100-5. doi: 10.1097/00007890-196707001-00045.
Abstract
Twenty patients were treated with antilymphocyte globulin (ALG) which was prepared from the serum of immunized horses. The ALG was used as an adjuvant to azathioprine and prednisone and its use limited to 4 months. The surviving patients are now 1 to 7 months postoperative. There was 1 death, the consequence of a technical accident. The function in the remaining 19 patients is excellent, despite reduced doses of azathioprine and especially prednisone. Biopsies were obtained in the first 8 consecutive cases from 108 to 145 days after operation. There was no evidence in the specimens of either Masugi-like or serum sickness nephritis.
摘要
20名患者接受了抗淋巴细胞球蛋白（ALG）治疗，该药物由免疫马的血清制备而成。ALG用作硫唑嘌呤和泼尼松的辅助药物，使用期限限制为4个月。存活患者目前处于术后1至7个月。有1例死亡，系技术事故所致。其余19名患者的功能良好，尽管硫唑嘌呤尤其是泼尼松的剂量有所减少。对连续8例患者在术后108至145天进行了活检。标本中未发现类马杉肾炎或血清病肾炎的证据。
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