深入了解 T 细胞生物学以及针对自身免疫、炎症和免疫抑制的 T 细胞靶向治疗。
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression.
机构信息
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Ann N Y Acad Sci. 2010 Jan;1183:123-48. doi: 10.1111/j.1749-6632.2009.05124.x.
Abstract
T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.
摘要
T 细胞定向疗法已成为各种自身免疫性疾病和器官移植管理的主要方法。自大多数目前使用的药物开发以来，T 细胞生物学的理解已经大大扩展。在这里，我们讨论了与辅助性 T 细胞分化、谱系决定和功能相关的重要最新发现。在这方面，我们检查了现有的 T 细胞定向疗法，包括正在临床和临床前研究中评估的新药物。我们还利用最近的发现来推测新的靶点。
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