Eloy R, Vaultier J P, Vuitton D, Pousse A, Grenier J F
Biomedicine. 1975 Apr 30;23(4):139-43.
To investigate the thymus-dependent immune competence of Peyer's patches, the course of splenomegaly and hepatic perivascular infiltration (PVI) was studied as criteria of graft-versus-host reaction (GvhR). Parental or F1 hybrid lymphoid tissues, were intrahepatically implanted and the ability of Peyer's patches to induce a GvhR was compared to that of spleen, lymph nodes and thymus. A slight but significant delayed increase of spleen index was observed at the 40th post operative day following Peyer's patches implantation whereas the thymus did not induce any modification of this parameter. On the other hand, the PVI was a very early and precise criterion in monitoring the Gvh reaction induced by Peyer's patches, and allowed to postulate that at least one T-cell function is present within the Peyer's patches.
为研究派尔集合淋巴结的胸腺依赖性免疫能力，以脾肿大进程和肝血管周围浸润（PVI）作为移植物抗宿主反应（GvhR）的标准进行了研究。将亲代或F1杂种淋巴组织植入肝内，并将派尔集合淋巴结诱导GvhR的能力与脾、淋巴结和胸腺的能力进行比较。在植入派尔集合淋巴结后的术后第40天观察到脾脏指数有轻微但显著的延迟增加，而胸腺并未引起该参数的任何改变。另一方面，PVI是监测派尔集合淋巴结诱导的Gvh反应的一个非常早期且精确的标准，并推测派尔集合淋巴结内至少存在一种T细胞功能。
