Kamiński M J, Szmurło A, Majewski S, Bem W, Kamińska G
Arch Immunol Ther Exp (Warsz). 1981;29(4):525-7.
Fragments of murine spleen and Peyer's patches were transplanted under the kidney capsule of syngeneic recipients. The ability of graft-repopulating cells to enhance cell-mediated immunity was tested in a lymphocyte-induced angiogenesis assay. The ability to evoke angiogenesis expressed by cells isolated from 10-day-old grafts of both tissues was significantly lower than that of cells isolated from organs in situ and was restored to control levels in both types of grafts 30 days after transplantation. Cells of Peyer's patch grafts showed weaker ability to induce angiogenesis than cells of spleen grafts regardless of the graft's age. Cells isolated from Peyer's patches in situ also showed weaker angiogenesis-inducing ability compared with normal spleen cells. Hence the results suggest that the repopulation of lymphoid tissue graft is specifically influenced by the graft's microenvironment.
将小鼠脾脏和派尔集合淋巴结的碎片移植到同基因受体的肾包膜下。在淋巴细胞诱导的血管生成试验中测试了移植物再填充细胞增强细胞介导免疫的能力。从这两种组织的10日龄移植物中分离出的细胞诱发血管生成的能力明显低于从原位器官中分离出的细胞，并且在移植后30天，这两种类型移植物中的细胞诱发血管生成的能力均恢复到对照水平。无论移植物的年龄如何，派尔集合淋巴结移植物的细胞诱导血管生成的能力都比脾脏移植物的细胞弱。与正常脾细胞相比，从原位派尔集合淋巴结中分离出的细胞诱导血管生成的能力也较弱。因此，结果表明淋巴组织移植物的再填充受到移植物微环境的特异性影响。
