Lacassagne A, Buu-Hoi N P, Zajdela F, Jacquigmon P, Mangane M
Science. 1967 Oct 20;158(3799):387-8. doi: 10.1126/science.158.3799.387.
The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.
标题化合物属于一类新的由异香豆素衍生的多环内酯合成基团，当注射到小鼠体内时，在原位表现出极高的致癌性。在类似的异香豆素中也发现了致癌活性，这是一个已知包含许多天然存在物质的家族。
