Investigations on the carcinogenic burden by air pollution in man. XVIII. The morphology of neoplasms induced in NMRI Mice after subcutaneous administration of PAH (individual or combination treatment).

A single s.c. dose of polycyclic aromatic hydrocarbons (PAH) administered individually or in combinations in the neck area to NMRI mice produced mainly malignant mesenchymal neoplasms at the injection site. Parts of these tumours frequently showed a high degree of polymorphism and, as a detailed examination of their morphology demonstrated were similar to sarcomas of the subcutaneous tissue observed in other animal models.