Jackson W B, Tolis G, Chertman M
Can J Ophthalmol. 1978 Jan;13(1):10-4.
When a goiter or hyperthyroidism is absent, the diagnosis of ophthalmic Graves' disease is often difficult. We evaluated the thyrotropin (TSH) response to intravenously administered thyrotropin-releasing hormone (TRH) in fourteen patients presenting with proptosis or lid retraction. All of them had normal results with routine thyroid function tests and in most a T3 suppression test and orbital ultrasonography were performed. We found an absent or impaired response to TRH in the patients with Graves' ophthalmopathy which correlates well with their having a non-suppressible thyroid gland. Patients with orbital tumours, pseudotumours or congenital lid retraction responded normally to TRH. The TRH test was easier and as reliable as the T3 suppression test in the investigation of a patient with suspected Graves' disease.
当不存在甲状腺肿或甲状腺功能亢进时，诊断眼型格雷夫斯病往往很困难。我们评估了14例有眼球突出或眼睑退缩症状患者对静脉注射促甲状腺激素释放激素（TRH）的促甲状腺激素（TSH）反应。他们的常规甲状腺功能检查结果均正常，大多数患者还进行了T3抑制试验和眼眶超声检查。我们发现格雷夫斯眼病患者对TRH无反应或反应受损，这与他们甲状腺不受抑制密切相关。患有眼眶肿瘤、假瘤或先天性眼睑退缩的患者对TRH反应正常。在疑似格雷夫斯病患者的检查中，TRH试验比T3抑制试验更简便且同样可靠。
