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精神分裂症的脑电图定性和定量研究结果(作者译)

[Qualitative and quantitative EEG-findings in schizophrenia (author's transl)].

作者信息

Itil T M

出版信息

EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1978 Mar;9(1):1-13.

PMID:416942
Abstract

The results of the qualitative but particularly the quantitative EEG-studies indicate that 1. The EEG of adult schizophrenics is characterized by an appearance of excessive fast activity along with some slow waves and the lack of alpha-activity. 2. Excessive fast activity and lack of alpha-waves have also been found in the EEGs of psychotic children and most interestingly in children whose parents (particularly the mother) are schizophrenic (high risk children). 3. Based on the studies during sleep and investigations with neuroleptics, it was established that the origin of the excess fast activity in schizophrenia cannot be the muscle potential. Particularly the excess fast activity in high risk children for schizophrenia goes against the muscle potential hypothesis. 4. The quantitative EEG changes seen in schizophrenia show similarity to those seen after hallucinogenic compounds particularly after anticholinergic hallucinogenics. 5. All neuroleptics (major tranquilizers) produce quantitative EEG alterations which are almost diametrically opposite to those seen in schizoprenia.

摘要

定性研究结果,尤其是定量脑电图研究结果表明:1. 成年精神分裂症患者的脑电图特征为出现过多的快波活动,伴有一些慢波,且缺乏α波活动。2. 在患有精神病的儿童脑电图中也发现了过多的快波活动,最有趣的是在其父母(尤其是母亲)患有精神分裂症的儿童(高危儿童)中。3. 根据睡眠期间的研究以及使用抗精神病药物的调查,已确定精神分裂症中快波活动过多的起源不可能是肌肉电位。尤其是精神分裂症高危儿童中过多的快波活动与肌肉电位假说相悖。4. 精神分裂症中观察到的定量脑电图变化与使用致幻化合物后,尤其是抗胆碱能致幻剂后观察到的变化相似。5. 所有抗精神病药物(主要镇静剂)都会产生定量脑电图改变,这些改变几乎与精神分裂症中观察到的改变完全相反。

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Neurobiological approaches in human behavior genetics.人类行为遗传学中的神经生物学方法。
Behav Genet. 1981 Mar;11(2):87-102. doi: 10.1007/BF01065620.
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The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. III. Interpretation of the results.
脑电图(EEG)作为人类行为遗传学的研究工具:对具有各种遗传性EEG变异的健康男性进行心理测试。III. 结果解读
Hum Genet. 1979 Feb 28;47(1):81-111. doi: 10.1007/BF00295571.