Goudie R B, McDonald E, Anderson J R, Gray K
Clin Exp Immunol. 1968 Feb;3(2):119-31.
The antibodies in the sera of two patients with idiopathic Addison's disease, one reacting specifically with adrenocortical cells, the other with the various cell types which produce steroid hormones, have been found to be predominently IgG. The behaviour of the two antibodies in complement-fixation tests is in agreement with their reactivity, reported in the previous paper, in immunofluorescence tests. Cell fractionation studies suggest that both adrenal antigens are associated with the microsomal fraction. The biochemical properties of the antigens are consistent with the view that they are lipoproteins, possibly with associated carbohydrate. While the properties of the adrenal antigens are generally similar to those of the thyroid and gastric parietal cell organ-specific autoantigens, they differ from these, and from each other, in their susceptibility to destruction by certain enzymes and chemical treatments.
两名特发性Addison病患者血清中的抗体，一种与肾上腺皮质细胞特异性反应，另一种与产生甾体激素的各种细胞类型反应，已发现主要为IgG。这两种抗体在补体结合试验中的表现与前一篇论文报道的它们在免疫荧光试验中的反应性一致。细胞分级分离研究表明，两种肾上腺抗原均与微粒体部分相关。抗原的生化特性与它们是脂蛋白（可能带有相关碳水化合物）的观点一致。虽然肾上腺抗原的特性通常与甲状腺和胃壁细胞器官特异性自身抗原相似，但它们在对某些酶和化学处理的敏感性方面与这些抗原以及彼此之间存在差异。
