Grossman Z D, Wistow B W, McAfee J G, Subramanian G, Thomas F D, Henderson R W, Rohner R F, Roskopf M L
J Nucl Med. 1978 May;19(5):488-91.
Using rabbit platelets harvested and labeled with either Tc-99m or In-111 oxine as described in Part 1, we have successfully imaged experimentally induced fresh venous thrombi and newly injured arterial intima. Visualization of lesions up to 6 hr old is striking. Thrombi and arterial damage 24 hr old, however, were usually not imaged successfully; nor were preformed platelet-poor arterial emboli. The varying rates of platelet deposition in vascular lesions of different ages and types account for these observations. Should human cells prove as effective, widespread clinical application is anticipated.
使用如第1部分所述收获并用Tc-99m或In-111氧嗪标记的兔血小板，我们已成功对实验诱导的新鲜静脉血栓和新损伤的动脉内膜进行成像。对长达6小时的损伤进行可视化效果显著。然而，24小时的血栓和动脉损伤通常无法成功成像；预先形成的血小板含量低的动脉栓子也不行。不同年龄和类型的血管损伤中血小板沉积速率不同，这就解释了这些观察结果。如果人类细胞证明同样有效，预计将得到广泛的临床应用。
