Ren Dan-Qi, Peng Hui-Zhen, Zhang Yue, Yue Yue, Chen Yu, Zhao Yun-Li, Yuan Ming-Long, Luo Xiao-Dong
Institute of International Rivers and Eco-security, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, School of Pharmacy, Yunnan University, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd, Southwest United Graduate School, Kunming, 650500, China.
Green Preparation Technology of Biobased Materials National & Local Joint Engineering Research Center, Yunnan Minzu University, Kunming, 650500, China.
J Mater Chem B. 2026 Feb 25. doi: 10.1039/d5tb02761f.
Poly(L-lactic acid) (PLLA) microspheres are widely used in aesthetic and regenerative medicine to promote collagen remodeling, but their efficacy and long-term safety lack sufficient experimental data. In this study, a poly(γ-glutamic acid)-thickened PLLA microsphere formulation (PLLA-γ-PGA) was developed, and its biocompatibility and efficacy were evaluated in an aged mice model induced by subcutaneous injection of D-galactose combined with UV irradiation. As a result, PLLA-γ-PGA significantly enhanced dermal fibroblast activation, promoted sustained tissue remodeling and elicited milder inflammatory responses without observable adverse effects, outperforming marketed hyaluronic acid (HA) fillers and PLLA-carboxymethyl cellulose sodium (PLLA-CMC) formulations. These findings present PLLA-γ-PGA as a safe and efficacious regenerative material, providing robust preclinical evidence to support its translational potential for long-term skin rejuvenation.
聚左旋乳酸（PLLA）微球在美容和再生医学中被广泛用于促进胶原蛋白重塑，但其疗效和长期安全性缺乏足够的实验数据。在本研究中，开发了一种聚γ-谷氨酸增稠的PLLA微球制剂（PLLA-γ-PGA），并在皮下注射D-半乳糖联合紫外线照射诱导的衰老小鼠模型中评估了其生物相容性和疗效。结果显示，PLLA-γ-PGA显著增强了真皮成纤维细胞的活化，促进了持续的组织重塑，并引发了较轻的炎症反应，且无明显不良反应，优于市售透明质酸（HA）填充剂和PLLA-羧甲基纤维素钠（PLLA-CMC）制剂。这些发现表明PLLA-γ-PGA是一种安全有效的再生材料，为支持其长期皮肤年轻化的转化潜力提供了有力的临床前证据。
