Katz R J, Liebler L
Psychopharmacology (Berl). 1978 Mar 1;56(2):191-3. doi: 10.1007/BF00431848.
In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning within sessions and a lack of consolidation across sessions. Controls, on the other hand, showed learning both within and across sessions. This evidence agrees with previous reports suggesting GABA involvement in memory processes.
为了评估中枢γ-氨基丁酸（GABA）激活对回避电击记忆巩固的可能影响，在实验后给成年雄性大鼠注射GABA转氨酶抑制剂氨氧乙酸（AOAA）。在九个间隔较长的实验阶段进行学习评估，每个阶段20次实验。接受AOAA治疗的动物在各实验阶段内表现出学习能力，但在不同实验阶段之间缺乏记忆巩固。另一方面，对照组在各实验阶段内和不同实验阶段之间均表现出学习能力。这一证据与之前表明GABA参与记忆过程的报告一致。
