Broekkamp C L, Le Pichon M, Lloyd K G
Psychopharmacology (Berl). 1984;83(1):122-5. doi: 10.1007/BF00427435.
Acquisition of passive avoidance following aversive conditioning to a dark compartment was measured in mice under the influence of one of seven benzodiazepines, the GABA-mimetic drug progabide or PK 9084, a nonbenzodiazepine ligand on benzodiazepine receptors. The drugs were administered prior to the training trial and retention was measured in the absence of the drug 24 h later. Oral administration (dose in mg/kg in parentheses) of flunitrazepam (0.1), lorazepam (1.0), nitrazepam (3.0), diazepam (10), flurazepam (10) and chlordiazepoxide (30), all prevented retention whereas progabide (100-800) and PPK 9084 (10-100) were ineffective. In comparison to effects on motor capacity none of the benzodiazepines was outstanding in its acquisition interfering effects.
在七种苯二氮䓬类药物、GABA模拟药物普罗加比或苯二氮䓬受体上的非苯二氮䓬类配体PK 9084之一的影响下，测量了对黑暗隔室进行厌恶条件反射后小鼠被动回避行为的获得情况。在训练试验前给药，24小时后在无药物的情况下测量记忆保持情况。口服氟硝西泮（0.1）、劳拉西泮（1.0）、硝西泮（3.0）、地西泮（10）、氟西泮（10）和氯氮䓬（30）均会阻碍记忆保持，而普罗加比（100 - 800）和PPK 9084（10 - 100）则无效。与对运动能力的影响相比，没有一种苯二氮䓬类药物在其对获得的干扰作用方面表现突出。
