Banki C M
Psychopharmacology (Berl). 1978 Mar 1;56(2):195-8. doi: 10.1007/BF00431849.
Cerebrospinal fluid 5-hydroxyindoleacetic acid level, and total blood serotonin content was measured in groups of manic and schizophrenic patients before and after 2, 4, 6, 10, 20, and 30 days of clozapine treatment. CSF 5-HIAA values were elevated after 2 and 4 days and returned to baseline levels after 6 days or more. Blood serotonin content, in contrast, increased gradually and remained high even after 30 days. Neither CSF 5-HIAA nor blood 5-HT correlated with age, drug dose, or clinical effectiveness, but some relationship between these and the sedative component of the clozapine action was observed.
在一组躁狂症患者和精神分裂症患者中，于氯氮平治疗的第2、4、6、10、20和30天前后测量脑脊液5-羟吲哚乙酸水平及全血血清素含量。脑脊液5-羟吲哚乙酸水平在2天和4天后升高，6天及更长时间后恢复至基线水平。相比之下，血清单胺素含量逐渐增加，甚至在30天后仍维持在较高水平。脑脊液5-羟吲哚乙酸和血清单胺素均与年龄、药物剂量或临床疗效无关，但观察到它们与氯氮平作用的镇静成分之间存在某种关系。
