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1
Comparative simultaneous measurement of cerebrospinal fluid 5-hydroxyindoleacetic acid and blood serotonin levels in delirium tremens and clozapine-induced delirious reaction.震颤谵妄和氯氮平所致谵妄反应中脑脊液5-羟吲哚乙酸与血液血清素水平的比较同步测量
J Neurol Neurosurg Psychiatry. 1978 May;41(5):420-4. doi: 10.1136/jnnp.41.5.420.
2
Cerebrospinal fluid amine metabolites in delirium tremens.震颤谵妄中的脑脊液胺类代谢产物
Psychiatr Clin (Basel). 1981;14(3):167-77. doi: 10.1159/000283913.
3
Alterations of cerebrospinal fluid 5-hydroxyindoleacetic acid, and total blood serotonin content during clozapine treatment.氯氮平治疗期间脑脊液5-羟吲哚乙酸及全血血清素含量的变化
Psychopharmacology (Berl). 1978 Mar 1;56(2):195-8. doi: 10.1007/BF00431849.
4
5-Hydroxyindolacetic acid and homovanillic acid are not involved in the cerebrospinal fluid after a seizure in patients with Delirium Tremens.在震颤谵妄患者癫痫发作后，5-羟吲哚乙酸和高香草酸与脑脊液无关。
Neurol Res. 2002 Sep;24(6):599-600. doi: 10.1179/016164102101200429.
5
Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients.在精神分裂症患者接受氟哌啶醇和氯氮平治疗期间的锥体外系反应及脑脊液中的胺代谢产物
Psychopharmacologia. 1975;40(4):341-50. doi: 10.1007/BF00421473.
6
Delirium tremens and related clinical states: changes in calcium and inorganic phosphate concentrations in plasma and cerebrospinal fluid.震颤谵妄及相关临床状态：血浆和脑脊液中钙及无机磷酸盐浓度的变化
Acta Psychiatr Scand. 1984 Mar;69(3):250-8. doi: 10.1111/j.1600-0447.1984.tb02492.x.
7
Magnesium concentrations in blood and cerebrospinal fluid during delirium tremens.震颤谵妄期间血液和脑脊液中的镁浓度。
Psychiatry Res. 1979 Oct;1(2):161-71. doi: 10.1016/0165-1781(79)90057-x.
8
Plasma immunoreactive insulin and somatotropin in delirium tremens and alcoholic hallucinosis.震颤谵妄和酒精性幻觉症中的血浆免疫反应性胰岛素和生长激素。
J Stud Alcohol. 1976 Mar;37(3):327-33. doi: 10.15288/jsa.1976.37.327.
9
[Biochemical studies in delirium tremens (author's transl)].震颤谵妄的生化研究（作者译）
Arzneimittelforschung. 1978;28(9):1527-8.
10
Clozapine pharmacology and tardive dyskinesia.氯氮平药理学与迟发性运动障碍
Psychopharmacology (Berl). 1989;99 Suppl:S54-9. doi: 10.1007/BF00442560.

引用本文的文献

1
Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium.血浆 5-HIAA 活性可提示认知障碍、老年术后谵妄患者存在 5-羟色胺能紊乱。
Int J Geriatr Psychiatry. 2022 Feb;37(2). doi: 10.1002/gps.5677.
2
5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders.5-羟吲哚乙酸作为神经和精神疾病的潜在生物标志物
Adv Pharm Bull. 2019 Aug;9(3):374-381. doi: 10.15171/apb.2019.044. Epub 2019 Aug 1.
3
Clinical pharmacology of old age syndromes.老年综合征的临床药理学
Br J Clin Pharmacol. 2003 Sep;56(3):261-72. doi: 10.1046/j.0306-5251.2003.01877.x.
4
A long-term follow-up study of cerebrospinal fluid 5-hydroxyindoleacetic acid in delirium.谵妄患者脑脊液5-羟色胺酸的长期随访研究
Eur Arch Psychiatry Clin Neurosci. 1994;244(3):131-4. doi: 10.1007/BF02191886.

本文引用的文献

1
Arterial noradrenaline levels after ethanol withdrawal.乙醇戒断后的动脉去甲肾上腺素水平。
Lancet. 1967 Oct 21;2(7521):889. doi: 10.1016/s0140-6736(67)92619-0.
2
5-Hydroxytryptamine metabolism in brain and liver slices and the effect of ethanol.脑和肝切片中的5-羟色胺代谢及乙醇的影响
J Neurochem. 1969 Feb;16(2):274-6. doi: 10.1111/j.1471-4159.1969.tb05946.x.
3
Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain.大鼠脑小区域中5-羟色胺和5-羟吲哚乙酸的快速测定方法。
Br J Pharmacol. 1970 Jul;39(3):653-5. doi: 10.1111/j.1476-5381.1970.tb10373.x.
4
The effect of ethanol on the in vivo conversion of 5-HTP-14C to serotonin-14C, 5-hydroxyindoleacetaldehyde-14C and its metabolites in rat brain.乙醇对大鼠脑中5-羟色氨酸-14C向血清素-14C、5-羟吲哚乙醛-14C及其代谢产物的体内转化的影响。
Int J Neuropharmacol. 1969 Jul;8(4):347-51. doi: 10.1016/0028-3908(69)90020-3.
5
Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.5-羟色胺在血小板中的代谢、转运与储存
Br J Pharmacol Chemother. 1968 Jan;32(1):1-16. doi: 10.1111/j.1476-5381.1968.tb00423.x.
6
A simple routine-method to preserve and determine blood serotonin.一种保存和测定血液中血清素的简单常规方法。
Experientia. 1974 Jul 15;30(7):837. doi: 10.1007/BF01924220.
7
Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness.情感性疾病中的精神运动活动与脑脊液胺类代谢产物
Am J Psychiatry. 1973 Jan;130(1):67-72. doi: 10.1176/ajp.130.1.67.
8
Biogenesis of biologically active alkaloids from amines by alcohol and acetaldehyde.通过乙醇和乙醛由胺类生物合成生物活性生物碱
Ann N Y Acad Sci. 1973 Apr 30;215:98-110. doi: 10.1111/j.1749-6632.1973.tb28255.x.
9
Ethanol-induced sleep in relation to serotonin turnover and conversion to 5-hydroxyindoleacetaldehyde, 5-hydroxytryptophol, and 5-hyroxyindoleacetic acid.乙醇诱导睡眠与血清素周转以及向5-羟吲哚乙醛、5-羟色醇和5-羟基吲哚乙酸的转化的关系。
Ann N Y Acad Sci. 1973 Apr 30;215:71-6. doi: 10.1111/j.1749-6632.1973.tb28250.x.
10
A further insight into the metabolism of certain -carbolines.对某些β-咔啉代谢的进一步洞察。
Ann N Y Acad Sci. 1973 Apr 30;215:120-3. doi: 10.1111/j.1749-6632.1973.tb28258.x.

震颤谵妄和氯氮平所致谵妄反应中脑脊液5-羟吲哚乙酸与血液血清素水平的比较同步测量

Comparative simultaneous measurement of cerebrospinal fluid 5-hydroxyindoleacetic acid and blood serotonin levels in delirium tremens and clozapine-induced delirious reaction.

作者信息

Banki C M, Vojnik M

出版信息

J Neurol Neurosurg Psychiatry. 1978 May;41(5):420-4. doi: 10.1136/jnnp.41.5.420.

DOI:10.1136/jnnp.41.5.420
PMID:660204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493048/
Abstract

Cerebrospinal fluid 5-hydroxyindoleacetic acid and total blood serotonin levels were measured simultaneously in 11 female patients with delirium tremens and nine schizophrenic women with clozapine-induced acute delirium. Both groups had significantly raised levels of 5HIAA in CSF and significantly reduced blood 5HT levels as compared with normal control subjects, symptom-free alcoholics, or clozapine-treated schizophrenics. The two delirious groups were not distinguishable from each other in respect of their CSF 5HIAA or blood 5HT values. After clinical recovery both values returned to normal levels.

摘要

对11名震颤谵妄女性患者和9名因氯氮平诱发急性谵妄的精神分裂症女性患者同时测定了脑脊液5-羟吲哚乙酸和全血血清素水平。与正常对照受试者、无症状酗酒者或接受氯氮平治疗的精神分裂症患者相比，两组患者脑脊液中5-羟吲哚乙酸水平均显著升高，血液中5-羟色胺水平显著降低。两组谵妄患者的脑脊液5-羟吲哚乙酸或血液5-羟色胺值并无差异。临床康复后，这两个值均恢复到正常水平。