震颤谵妄和氯氮平所致谵妄反应中脑脊液5-羟吲哚乙酸与血液血清素水平的比较同步测量
Comparative simultaneous measurement of cerebrospinal fluid 5-hydroxyindoleacetic acid and blood serotonin levels in delirium tremens and clozapine-induced delirious reaction.
作者信息
Banki C M, Vojnik M
出版信息
J Neurol Neurosurg Psychiatry. 1978 May;41(5):420-4. doi: 10.1136/jnnp.41.5.420.
Abstract
Cerebrospinal fluid 5-hydroxyindoleacetic acid and total blood serotonin levels were measured simultaneously in 11 female patients with delirium tremens and nine schizophrenic women with clozapine-induced acute delirium. Both groups had significantly raised levels of 5HIAA in CSF and significantly reduced blood 5HT levels as compared with normal control subjects, symptom-free alcoholics, or clozapine-treated schizophrenics. The two delirious groups were not distinguishable from each other in respect of their CSF 5HIAA or blood 5HT values. After clinical recovery both values returned to normal levels.
摘要
对11名震颤谵妄女性患者和9名因氯氮平诱发急性谵妄的精神分裂症女性患者同时测定了脑脊液5-羟吲哚乙酸和全血血清素水平。与正常对照受试者、无症状酗酒者或接受氯氮平治疗的精神分裂症患者相比，两组患者脑脊液中5-羟吲哚乙酸水平均显著升高，血液中5-羟色胺水平显著降低。两组谵妄患者的脑脊液5-羟吲哚乙酸或血液5-羟色胺值并无差异。临床康复后，这两个值均恢复到正常水平。
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