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[血管解痉剂作用机制的实验。4. 硝普钠、硝酸甘油、普尼拉明和维拉帕米对平滑肌微粒体钙摄取的影响]

[Experiments on the mechanism of action of vascular spasmolytics. 4. Effect of nitroprusside sodium, nitroglycerin, prenylamine and verapamil on the calcium uptake of microsomes of the smooth bascular muscles].

作者信息

Klinner U, Ehlers D, Fermum R, Meisel P

出版信息

Acta Biol Med Ger. 1977;36(7-8):1143-8.

PMID:417536
Abstract

Nitroprusside-sodium, nitroglycerol, and verapamil had no effect on the calcium uptake by microsomes from the carotid artery of cattle. Prenylamine reduced the passive binding and the active uptake and released already bound calcium. The basal Mg-dependendent ATPase and Ca-stimulatable Mg-ATPase were inhibited by prenylamine.

摘要

硝普钠、硝酸甘油和维拉帕米对牛颈动脉微粒体摄取钙没有影响。普尼拉明减少了被动结合和主动摄取,并释放已结合的钙。普尼拉明抑制基础镁依赖性ATP酶和钙刺激的镁-ATP酶。

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