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怀孕恒河猴的锌缺乏:对幼猴行为的影响。

Zinc deficiency in pregnant rhesus monkeys: effects on behavior of infants.

作者信息

Sandstead H H, Strobel D A, Logan G M, Marks E O, Jacob R A

出版信息

Am J Clin Nutr. 1978 May;31(5):844-9. doi: 10.1093/ajcn/31.5.844.

DOI:10.1093/ajcn/31.5.844
PMID:417617
Abstract

Zinc deprivation from day 110 to 150 of gestation in rhesus monkeys resulted in rash, alopecia, anorexia, decreased feed efficiency, and low plasma zinc in the mothers. Infants of the dams that had been deprived of zinc during gestation displayed a more rapid postnatal growth rate than infants of the control mothers. Infants of the zinc-deprived dams played and explored less than the control infants. They also associated with their mothers a greater percentage of the time and were less active. This study has shown that third trimester maternal zinc deprivation in nonhuman primates can impair behavioral development of offspring.

摘要

在恒河猴孕期的第110天至150天剥夺锌元素,导致母猴出现皮疹、脱发、厌食、饲料效率降低以及血浆锌含量低的情况。孕期被剥夺锌元素的母猴所生的幼崽,其出生后的生长速度比对照组母猴所生的幼崽更快。锌缺乏母猴所生的幼崽玩耍和探索的次数比对照组幼崽少。它们与母亲相处的时间比例也更高,且活动较少。这项研究表明,非人灵长类动物孕期晚期母体锌缺乏会损害后代的行为发育。

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Zinc deficiency in pregnant rhesus monkeys: effects on behavior of infants.怀孕恒河猴的锌缺乏:对幼猴行为的影响。
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引用本文的文献

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Severe Zinc Deficiency Impairs Accrual of Bone in Rapidly Growing Rats That Is Partially Corrected Following Short-term Zinc Repletion.严重锌缺乏会损害快速生长的大鼠的骨量积累,而短期补锌后可部分纠正这一现象。
Biol Trace Elem Res. 2023 Aug;201(8):3834-3849. doi: 10.1007/s12011-022-03456-4. Epub 2022 Nov 9.
2
Impact of Zinc Transport Mechanisms on Embryonic and Brain Development.锌转运机制对胚胎和脑发育的影响。
Nutrients. 2022 Jun 17;14(12):2526. doi: 10.3390/nu14122526.
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Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons.
支架蛋白和锌离子介导发育中神经元的AMPA受体亚基转换。
Front Mol Neurosci. 2018 Nov 9;11:405. doi: 10.3389/fnmol.2018.00405. eCollection 2018.
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Behavioral impairments in animal models for zinc deficiency.锌缺乏动物模型中的行为障碍。
Front Behav Neurosci. 2015 Jan 6;8:443. doi: 10.3389/fnbeh.2014.00443. eCollection 2014.
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Biochemical alteration of a metallothionein-like protein in developing rat brain.发育中大鼠脑内一种金属硫蛋白样蛋白的生化改变。
Biol Trace Elem Res. 1986 Dec;11(1):117-28. doi: 10.1007/BF02795529.
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A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders.突触锌在自闭症谱系障碍中 ProSAP/Shank PSD 支架畸形中的作用。
Dev Neurobiol. 2014 Feb;74(2):136-46. doi: 10.1002/dneu.22089. Epub 2013 Sep 11.
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Environmental factors in autism.自闭症的环境因素。
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