补体系统与内毒素脂多糖的相互作用：六种末端补体成分各自的消耗情况。
Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components.
作者信息
Gewurz H, Shin H S, Mergenhagen S E
出版信息
J Exp Med. 1968 Nov 1;128(5):1049-57. doi: 10.1084/jem.128.5.1049.
Abstract
Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.
摘要
当豚鼠血清与内毒素脂多糖、酵母聚糖或预先形成的免疫复合物一起孵育时，大量的C3、C5、C6、C7、C8和C9会被消耗。由于这些补体成分参与了将内毒素注射到实验动物体内后产生的几种生物学活性，这些实验支持了这样一种假说，即内毒素诱导的某些生物学效应可能是通过补体系统介导的，并且可能解释了内毒素和免疫复合物在体内引起的反应中一些已知的相似性。
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本文引用的文献
1
THE ROLE OF THE COMPONENTS OF COMPLEMENT IN SPECIFIC IMMUNE FIXATION.补体成分在特异性免疫固定中的作用。
J Exp Med. 1942 Apr 1;75(4):421-35. doi: 10.1084/jem.75.4.421.
2
A LABILE SERUM FACTOR IN EXPERIMENTAL ENDOTOXIN SHOCK: CROSS-TRANSFUSION STUDIES IN DOGS.实验性内毒素休克中的一种不稳定血清因子：犬的交叉输血研究。
J Exp Med. 1961 Sep 30;114(4):501-8. doi: 10.1084/jem.114.4.501.
3
Funnies on capitol hill.国会山上的趣事。
Science. 1967 Mar 10;155(3767):1222. doi: 10.1126/science.155.3767.1222.
4
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
5
THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.血清补体在体外白细胞趋化性中的作用
J Exp Med. 1965 Aug 1;122(2):327-46. doi: 10.1084/jem.122.2.327.
6
ULTRASTRUCTURE OF VEILLONELLA AND MORPHOLOGICAL CORRELATION OF AN OUTER MEMBRANE WITH PARTICLES ASSOCIATED WITH ENDOTOXIC ACTIVITY.韦荣球菌的超微结构以及外膜与内毒素活性相关颗粒的形态学关联
J Bacteriol. 1964 Nov;88(5):1482-92. doi: 10.1128/jb.88.5.1482-1492.1964.
7
LESIONS IN ERYTHROCYTE MEMBRANES CAUSED BY IMMUNE HAEMOLYSIS.免疫性溶血导致的红细胞膜病变
Nature. 1964 Apr 18;202:251-2. doi: 10.1038/202251a0.
8
THE EFFECT OF ADJUVANT AMOUNTS OF ENDOTOXINS ON THE SERUM HEMOLYTIC COMPLEMENT ACTIVITY IN RABBITS.佐剂剂量的内毒素对家兔血清溶血补体活性的影响。
J Immunol. 1963 Dec;91:748-56.
9
Reduction of serum complement in rabbits after injection of endotoxin.注射内毒素后家兔血清补体的降低。
J Exp Med. 1962 Oct 1;116(4):477-90. doi: 10.1084/jem.116.4.477.
10
Studies on the mechanism of hypersensitivity phenomena. III. The participation of complement in the formation of anaphylatoxin.过敏反应现象机制的研究。III. 补体在过敏毒素形成中的参与作用。
J Exp Med. 1959 Aug 1;110(2):311-39. doi: 10.1084/jem.110.2.311.
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