Blanco A, Solís P, Alvarez Guisasola F J, Valbuena C, Gómez C, Prieto P, Ruíz C
An Esp Pediatr. 1980 Aug;13(8):679-88.
Various complement components (C'1s, C'3, C'4, C'5, C'8, C'9, C'3 act., C'1 inh., C'3b inact.) and seric immunocomplexes (by polyethylene glycol, PEG) were evaluated in 43 children with meningococcal sepsis. 28 patients had disseminated intravascular coagulation (DIC), group I, and 15 did not show it, group II; 14 patients died in group I and none of group II. In 21 cases studies were repeated 24 hours later. In group I all complement components were decreased, specially C'3 (x: 67 mg./100 ml., p < 0.01) and C'5 (x: 8 mg./100 ml., p < 0.01) and they were lower 24 h. later. Results of group II were normal, except a decrease of C'5. Catabolic products of C'3 were founded in 11/14 cases of group I and two/nine of group II and products of C'3 act. in four/14 and one/10. PEG precipitation was positive in 10/14 cases of group I and 10/12 of group II and IgG, IgM, C'3 and C'4 were found in precipitations. This complement components were more frequently present in sepsis without DIC and after 24 h. of evolution. C'1 and C'3b inhibitors decreased after evolution in group I and by contrast increased in group II. This fall enhances complement activation.
对43例患脑膜炎球菌败血症的儿童评估了各种补体成分（C'1s、C'3、C'4、C'5、C'8、C'9、C'3活性、C'1抑制物、C'3b灭活物）和血清免疫复合物（采用聚乙二醇，PEG）。28例患者发生弥散性血管内凝血（DIC），为I组，15例未发生弥散性血管内凝血，为II组；I组14例患者死亡，II组无死亡病例。21例患者在24小时后重复进行了研究。I组所有补体成分均降低，尤其是C'3（均值：67mg/100ml，p<0.01）和C'5（均值：8mg/100ml，p<0.01），且24小时后更低。II组结果正常，除C'5降低外。I组14例中的11例及II组9例中的2例检测到C'3的分解产物，I组14例中的4例及II组10例中的1例检测到C'3活性产物。I组14例中的10例及II组12例中的10例PEG沉淀呈阳性，沉淀中发现IgG、IgM、C'3和C'4。这些补体成分在无DIC的败血症及病程24小时后更常见。I组病程进展后C'1和C'3b抑制物降低，而II组则相反升高。这种降低增强了补体激活。
