Azen E A, Smithies O
Science. 1968 Nov 22;162(3856):905-7. doi: 10.1126/science.162.3856.905.
Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C3(1), 0.21; C3(2), 0.77; C3(3), approximately 0.01; and C3(4), approximately 0.004.
通过高压淀粉凝胶电泳已在人血清中检测到人类补体第三成分及其裂解产物的遗传多态性。在对113名随机选择的高加索人的研究中观察到六种表型。它们的遗传由常染色体位点上的四个共显性等位基因控制。本研究中的基因频率为C3(1)，0.21；C3(2)，0.77；C3(3)，约0.01；C3(4)，约0.004。
