Kador P F, Sharpless N E
Biophys Chem. 1978 Mar;8(1):81-5. doi: 10.1016/0301-4622(78)85025-x.
Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.
对各种4-氧代-4H-色烯-2-羧酸及其衍生物进行了醛糖还原酶抑制活性筛选。它们与几种黄酮类化合物的抑制反应已与简单的休克尔分子轨道计算相关联。根据这些结果推测了一种可能的作用模式。
