Keller G, Leuenberger P M
Klin Monbl Augenheilkd. 1980 Apr;176(4):514-5. doi: 10.1055/s-2008-1057488.
Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes. We have tested the inhibitory activity of new flavone derivatives on a homogenate of lens epithelium. Compounds which inhibited the enzyme activity by more than 50 percent at 10(-60) M were then tested on rat lenses perfused in a 0.027 M glucose solution. Our preliminary studies indicate that these new flavone derivatives can prevent or delay the formation of cataract in an in-vitro model.
黄酮类化合物被认为是醛糖还原酶的有效抑制剂，醛糖还原酶是一种可能引发糖尿病性白内障形成的酶。我们测试了新型黄酮衍生物对晶状体上皮匀浆的抑制活性。然后，对在0.027M葡萄糖溶液中灌注的大鼠晶状体测试了在10(-6)M浓度下酶活性抑制率超过50%的化合物。我们的初步研究表明，这些新型黄酮衍生物在体外模型中可以预防或延缓白内障的形成。
