Knowles D M, Shevchuk M
Cancer. 1978 May;41(5):1883-9. doi: 10.1002/1097-0142(197805)41:5<1883::aid-cncr2820410532>3.0.co;2-l.
Pleomorphic reticulum cell sarcoma, a histologic variant of the histiocytic lymphomas, presented as an abdominal mass in a 52-year-old woman. Extensive amyloid deposition was present within the tumor mass and an M-component (IgG Lambda) was identified in the serum. Direct immunoperoxidase staining of tissue sections demonstrated the same monoclonal immunoglobulin to be present within the neoplastic cells, presumptive evidence of their ability to both synthesize and secrete immunoglobulin. The presence of amyloid within this patient was probably the direct result of the tissue deposition of this monoclonal immunoglobulin and may be related to the amyloidogenic nature of Lambda light chains. Immunoglobulin production is a specific property of the B lymphocyte series. Transforming B lymphocytes and their differentiating progeny are engaged in active immunoglobulin synthesis and thus may be distinguished from morphologically identical but functionally distinct cells. The demonstration of cytoplasmic monoclonal immunoglobulin within these "malignant reticulum cells" strongly supports the assertion that at least some "histiocytic lymphomas" are neoplastic analogues of transformed B lymphocytes, and are not derived from phagocytic histiocytes, as previously believed.
多形性网状细胞肉瘤是组织细胞淋巴瘤的一种组织学变异型，表现为一名52岁女性的腹部肿块。肿瘤块内存在广泛的淀粉样蛋白沉积，血清中鉴定出M成分（IgG λ）。组织切片的直接免疫过氧化物酶染色显示肿瘤细胞内存在相同的单克隆免疫球蛋白，推测这是它们合成和分泌免疫球蛋白能力的证据。该患者体内淀粉样蛋白的存在可能是这种单克隆免疫球蛋白组织沉积的直接结果，并且可能与λ轻链的淀粉样变性性质有关。免疫球蛋白的产生是B淋巴细胞系列的特异性特性。转化的B淋巴细胞及其分化后代参与活跃的免疫球蛋白合成，因此可以与形态相同但功能不同的细胞区分开来。在这些“恶性网状细胞”内显示细胞质单克隆免疫球蛋白有力地支持了这样一种观点，即至少一些“组织细胞淋巴瘤”是转化B淋巴细胞的肿瘤类似物，而不是如先前认为的那样来源于吞噬性组织细胞。
