Staples P J, Talal N
J Exp Med. 1969 Jan 1;129(1):123-39. doi: 10.1084/jem.129.1.123.
Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.
在6周龄的新西兰黑鼠（NZB）或B/W小鼠中无法诱导出对超速离心牛γ球蛋白的免疫耐受性，但在C3H、新西兰白兔（NZW）和C57Bl小鼠中则很容易形成。NZB和B/W小鼠以及Balb/c小鼠对超速离心人γ球蛋白均不能产生耐受性。NZB和B/W小鼠对标准抗原攻击也表现出更高的抗体滴度。这种免疫反应亢进和缺乏实验性耐受性可能与这些小鼠在较晚年龄出现的自身耐受性缺失、自身免疫和淋巴瘤有关。
