20至38周龄小鼠对口服耐受诱导的易感性降低及对卵清蛋白口服免疫的发生。口服免疫中口服暴露间隔和抗原摄取率的影响。
Decrease in susceptibility to oral tolerance induction and occurrence of oral immunization to ovalbumin in 20-38-week-old mice. The effect of interval between oral exposures and rate of antigen intake in the oral immunization.
作者信息
Faria A M, Garcia G, Rios M J, Michalaros C L, Vaz N M
机构信息
Departmento de Microbiologia, Instituto de Ciências Biológicas, UFMG, Belo Horizonte, Brazil.
出版信息
Immunology. 1993 Jan;78(1):147-51.
Abstract
Maturation into adulthood, from 8 to 24 weeks of age, significantly influences the induction of oral tolerance in different strains of mice. Animals from strains which are susceptible to the induction of oral tolerance to ovalbumin (OVA) at 8 weeks of age become refractory at 24 weeks of age. Furthermore, in several strains, intermittent exposure to OVA exclusively by gavage resulted in high titres of circulating anti-OVA antibodies. However, the voluntary intake of similar doses of OVA at the same intervals failed to immunize mice of one of the most responsive strains, H-III.
摘要
从8周到24周龄成熟进入成年期，会显著影响不同品系小鼠口服耐受性的诱导。8周龄时易诱导对卵清蛋白（OVA）产生口服耐受性的品系动物，在24周龄时变得难治。此外，在几个品系中，仅通过灌胃间歇性接触OVA会导致循环抗OVA抗体的高滴度。然而，以相同间隔自愿摄入相似剂量的OVA未能使反应性最强的品系之一H-III的小鼠产生免疫。
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Concomitant anaphylactic sensitization and contact unresponsiveness following the infusion or feeding of picryl chloride to guinea pigs.给豚鼠输注或喂食苦味酸氯后伴随的过敏致敏和接触无反应性。
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