Hecquet C, Loizeau M, Fontagné J, Blondelon D, Adolphe M, Lechat P
C R Acad Hebd Seances Acad Sci D. 1977 Dec 19;285(16):1503-6.
Formation of colonies from mice bone marrow progenitors of macrophages and granulocytes in methylcellulose culture was induced by an inflammatory pleural exudate obtained from mice injected with dextran. Mitogenic activity of this acute inflammatory exudate was compared with that of colony stimulating factor (CSF). It was found that colony and cluster counts, during 10 days of culture, were similar with the two types of stimulating factors. When used at the same dose, exudate was less active than CSF. It was concluded that inflammatory exudate showed an activity similar to that of CSF but contained a smaller amount of stimulating factor. Further cytochemical studies are necessary to specify whether or not the two factors induced the same type of colonies (monocytic or granulocytic).
从注射葡聚糖的小鼠获得的炎性胸腔渗出液可诱导小鼠骨髓巨噬细胞和粒细胞祖细胞在甲基纤维素培养物中形成集落。将这种急性炎性渗出液的促有丝分裂活性与集落刺激因子（CSF）的促有丝分裂活性进行了比较。结果发现，在培养的10天内，两种刺激因子的集落和簇计数相似。当以相同剂量使用时，渗出液的活性低于CSF。得出的结论是，炎性渗出液显示出与CSF相似的活性，但所含刺激因子的量较少。需要进一步进行细胞化学研究，以确定这两种因子是否诱导相同类型的集落（单核细胞或粒细胞）。
