Goldzieher J W, Chenault C B, de la Peña A, Dozier T S, Kraemer D C
Fertil Steril. 1978 Apr;29(4):388-96. doi: 10.1016/s0015-0282(16)43211-5.
The effects of ethynylestradiol or mestranol given in cyclic fashion, with and without a progestational compound (norethindrone acetate, dl-norgestrel, or megestrol acetate), on plasma androgens and their binding were examined in adult women, female baboons, and beagles. The two estrogens are equivalent in their effect, and there were essentially no dose-related differences over the range examined. In human subjects, the estrogens increased total testosterone and testosterone binding, and decreased free testosterone. In baboons, estrogen produced a transient decrease in total testosterone and an increase in binding. The levels of progestational agents used did not affect total testosterone in humans, as is commonly observed with commercial agents, but did decrease it in baboons. Percentage binding was decreased in both species by the 19-nor compounds, but not by megestrol. Androstenedione levels were unaffected in human subjects, but effects of both estrogens and progestins were seen in baboons. Because of the very low levels of androgens in female beagles, this species did not lend itself well to a study of this kind. However, an increase in testosterone binding was induced by estrogen even in the absence of testosterone/estrogen-binding globulin.
以周期性方式给予乙炔雌二醇或炔雌醇，同时使用或不使用孕激素化合物（醋酸炔诺酮、左炔诺孕酮或醋酸甲地孕酮），观察其对成年女性、雌性狒狒和比格犬血浆雄激素及其结合情况的影响。这两种雌激素效果相当，在所研究的剂量范围内基本没有剂量相关差异。在人类受试者中，雌激素使总睾酮和睾酮结合增加，游离睾酮降低。在狒狒中，雌激素使总睾酮短暂降低，结合增加。所用孕激素制剂的水平在人类中不影响总睾酮，这是商业制剂常见的情况，但在狒狒中会使其降低。19-去甲化合物使两个物种的结合百分比降低，但甲地孕酮不会。雄烯二酮水平在人类受试者中未受影响，但在狒狒中观察到雌激素和孕激素都有作用。由于雌性比格犬的雄激素水平非常低，该物种不太适合进行此类研究。然而，即使在没有睾酮/雌激素结合球蛋白的情况下，雌激素也能诱导睾酮结合增加。
