人体中35S标记抗甲状腺药物的代谢
Metabolism of 35S-labelled antithyroid drugs in man.
作者信息
Alexander W D, Evans V, MacAulay A, Gallagher T F, Londono J
出版信息
Br Med J. 1969 May 3;2(5652):290-1. doi: 10.1136/bmj.2.5652.290.
Abstract
Differences in the metabolic fate of antithyroid drugs influence the optimal frequency of administration and their therapeutic efficacy. (35)S propylthiouracil differed from the (35)S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status. Further work is required to determine the optimal frequency of administration for each compound.
摘要
抗甲状腺药物代谢命运的差异会影响给药的最佳频率及其治疗效果。放射性硫标记的丙硫氧嘧啶与放射性硫标记的咪唑类药物（卡比马唑和甲巯咪唑）不同，前者吸收和排泄更快，血浆中的生物半衰期更短。肾功能对药物生物半衰期的影响可能比甲状腺状态更为重要。需要进一步开展研究以确定每种化合物的最佳给药频率。
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