甲亢患者口服卡比马唑和甲巯咪唑后甲巯咪唑的药代动力学。
The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
作者信息
Skellern G G, Knight B I, Low C K, Alexander W D, McLarty D G, Kalk W J
出版信息
Br J Clin Pharmacol. 1980 Feb;9(2):137-43. doi: 10.1111/j.1365-2125.1980.tb05823.x.
Abstract
1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.
摘要
- 在两组甲状腺功能亢进患者口服卡比马唑或甲巯咪唑后，测量了甲巯咪唑的血浆浓度。2. 采用高效液相色谱法还能够测量一名患者中甲巯咪唑代谢物3 - 甲基 - 2 - 硫代乙内酰脲的浓度。3. 观察到个体间存在较大差异，尤其是在卡比马唑组中。4. 卡比马唑吸收不完全可解释分布表观容积和表观清除率特别高的原因。
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本文引用的文献
1
Antithyroid substances. 2. Some mercaptoglyoxalines, mercaptothiazoles and thiohydantoins.
Biochem J. 1951 Jun;49(1):125-8. doi: 10.1042/bj0490125.
2
A new route to the imidazole-2-thiones from 2-thiohydantoins. Implications in the study of ergothioneine.
Biochem J. 1968 Sep;109(2):209-15. doi: 10.1042/bj1090209.
3
Development and comparison of thin-layer chromatographic and gas-liquid chromatographic methods for measurement of methimazole in rat urine.
J Chromatogr. 1970 Dec;53(2):285-91. doi: 10.1016/s0021-9673(01)98469-9.
4
Proceedings: Changes in drug metabolizing ability in thyroid disease.
Br J Pharmacol. 1973 Sep;49(1):156P-157P.
5
Serum propylthiouracil: determination by a direct colorimetric procedure.
Clin Chem. 1972 Nov;18(11):1373-5.
6
Metabolism of 35S-labelled antithyroid drugs in man.
Br Med J. 1969 May 3;2(5652):290-1. doi: 10.1136/bmj.2.5652.290.
7
The acclumulation of 35 S-antithyroid drugs by the thyroid gland.
J Clin Endocrinol Metab. 1972 May;34(5):847-51. doi: 10.1210/jcem-34-5-847.
8
Methimazole: its absorption and excretion in man and tissue distribution in rats.
J Clin Endocrinol Metab. 1971 Aug;33(2):182-5. doi: 10.1210/jcem-33-2-182.
9
Altered plasma half-lives of antipyrine, propylthiouracil, and methimazole in thyroid dysfunction.
Clin Pharmacol Ther. 1975 Jan;17(1):48-56. doi: 10.1002/cpt197517148.
10
Identification of 3-methyl-2-thiohydantoin, a metabolite of carbimazole, in man.
Xenobiotica. 1977 Apr;7(4):247-53. doi: 10.3109/00498257709035782.
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