用于检测眼部黑色素瘤的潜在放射性药物。第一部分。5-碘-2-硫脲衍生物。
Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives.
作者信息
van Langevelde A, Bakker C N, Broxterman H J, Journée-de Korver J G, Kaspersen F M, Oosterhuis J A, Pauwels E K
出版信息
Eur J Nucl Med. 1983;8(2):45-51. doi: 10.1007/BF00252555.
The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1-3 h) was observed. Because of retention of the 131I activity in the tumour, high tumour/non-tumour tissue ratios were found (e.g. tumour/eye 2.3-10, tumour/skin 1.5-3) suggesting that some of these compounds might be used as melanoma delineating agents, when labelled with 123I.
在患有格林黑色素瘤的叙利亚金黄地鼠中测量了多种5-[¹³¹I]-碘-2-硫脲衍生物的组织分布。这些化合物在不到1小时内迅速分布于所有组织，而在大多数组织中观察到快速消除（半衰期为1-3小时）。由于¹³¹I活性在肿瘤中保留，发现肿瘤/非肿瘤组织比值很高（例如，肿瘤/眼睛为2.3-10，肿瘤/皮肤为1.5-3），这表明其中一些化合物用¹²³I标记时可能用作黑色素瘤显像剂。
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