de Carvalho I F, de Oliveira H L, Laus-Filho J A, Sarti W
Immunology. 1969 May;16(5):633-41.
The intravenous administration of nephrotoxic antibody serum to rats produced a rapid and pronounced reduction in the serum complement level; this was observed before lung lesions became apparent. A total suppression of the acute immune lung change was observed in animals depleted of complement by treatment with heat-aggregated human γ-globulin or zymosan. Albeit the experimental evidence presented is of indirect nature, it suggests that the complement system is involved in the mediation of the acute pulmonary injury following injection of nephrotoxic antibody serum.
给大鼠静脉注射肾毒性抗体血清后，血清补体水平迅速且显著降低；这一现象在肺部病变明显出现之前就已观察到。在用热聚集人γ球蛋白或酵母聚糖处理使补体耗竭的动物中，观察到急性免疫性肺部变化被完全抑制。尽管所呈现的实验证据具有间接性质，但它表明补体系统参与了注射肾毒性抗体血清后急性肺损伤的介导过程。
