Timoney J
Immunology. 1970 Oct;19(4):561-7.
The intraperitoneal administration of heat-aggregated sheep γ-globulin to mice caused a greater than sixfold decline in serum complement. Decomplementation significantly decreased the mean time to death of mice infected intraperitoneally with , but final mortality in normal and decomplemented groups of mice was similar. When the challenge bacteria were pretreated with fresh mouse serum, decomplementation had no effect and mice survived a lethal challenge of serum-treated organisms. This protective property was removed by heating the mouse serum to 56° for 30 minutes. Decomplementation did not affect the progress of infection in mice with acquired antibody. This suggests that complement protects by opsonization.
给小鼠腹腔注射热聚集的绵羊γ球蛋白导致血清补体下降超过六倍。补体灭活显著缩短了腹腔感染[具体细菌名称缺失]小鼠的平均死亡时间，但正常组和补体灭活组小鼠的最终死亡率相似。当用新鲜小鼠血清预处理攻击细菌时，补体灭活没有影响，小鼠在接受血清处理的生物体的致死性攻击后存活下来。将小鼠血清加热至56℃ 30分钟可消除这种保护特性。补体灭活不影响获得性抗体小鼠的[具体感染名称缺失]感染进程。这表明补体通过调理作用发挥保护作用。
