Liang Yi-Fang, Qu Wen-Wen, Zhu Meng-Die, Liu Gao-Fei, Zheng Xue, Jiang Qi, Han Yong-Li, Wang Qingbo
School of Acupuncture and Moxibustion, Henan University of Chinese Medicine, Zhengzhou,China.
Acupuncture Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Medicine (Baltimore). 2026 Mar 13;105(11):e47743. doi: 10.1097/MD.0000000000047743.
This study aimed to evaluate the efficacy of acupuncture combined with Chinese herbal medicine in the treatment of gastric ulcers (GU) through a meta-analysis.
A comprehensive search was conducted in Chinese databases (CNKI, VIP, and Wanfang) and international databases (PubMed, Embase, and the Cochrane Library) to identify available randomized controlled trials (RCTs) published from the inception of each database through January 2025. The primary outcomes considered included overall efficacy rate, Helicobacter pylori (Hp) eradication rate, recurrence rate, gastrin levels, and adverse events. The quality of each included study was assessed using the Cochrane Collaboration's Risk of Bias Tool, and data were analyzed using RevMan 5.3 software.
A total of 1288 articles were initially identified, of which 17 RCTs involving 1632 patients were ultimately included. The meta-analysis demonstrated that acupuncture combined with Chinese herbal medicine was superior to non-acupuncture combined with Chinese herbal medicine in terms of clinical efficacy (OR = 4.83, 95% confidence intervals [CI] = 3.36-6.93, P < .00001), Hp eradication rate (OR = 3.94, 95% CI = 2.35-6.6, P < .00001), recurrence rate (OR = 0.19, 95% CI = 0.1-0.35, P < .00001), and gastrin levels (MD = -18.39, 95% CI = -20.68 to -16.11, P < .00001). Due to the small sample size and low quality of the RCTs included, the overall certainty of the evidence is low.
Compared with the control intervention measures, acupuncture combined with traditional Chinese medicine therapy may be an effective complementary therapy for treating GU. It has shown good clinical efficacy, significantly improving the eradication rate of Hp, gastrin levels, and having a relatively low recurrence rate. No increase in adverse events has been reported, suggesting a favorable safety profile in clinical practice. However, further high-quality, large-scale studies are needed to confirm these results.
本研究旨在通过荟萃分析评估针灸联合中药治疗胃溃疡（GU）的疗效。
在中国数据库（知网、维普和万方）和国际数据库（PubMed、Embase和考克兰图书馆）中进行全面检索，以识别从各数据库建库至2025年1月发表的可用随机对照试验（RCT）。所考虑的主要结局包括总有效率、幽门螺杆菌（Hp）根除率、复发率、胃泌素水平和不良事件。使用考克兰协作网的偏倚风险工具评估每项纳入研究的质量，并使用RevMan 5.3软件进行数据分析。
最初共识别出1288篇文章，最终纳入17项RCT，涉及1632例患者。荟萃分析表明，针灸联合中药在临床疗效（OR = 4.83，95%置信区间[CI] = 3.36 - 6.93，P <.00001）、Hp根除率（OR = 3.94，95% CI = 2.35 - 6.6，P <.00001）、复发率（OR = 0.19，95% CI = 0.1 - 0.35，P <.00001）和胃泌素水平（MD = -18.39，95% CI = -20.68至 -16.11，P <.00001）方面优于非针灸联合中药。由于纳入的RCT样本量小且质量低，证据的总体确定性较低。
与对照干预措施相比，针灸联合中医治疗可能是治疗GU的一种有效辅助疗法。它已显示出良好的临床疗效，显著提高了Hp根除率和胃泌素水平，且复发率相对较低。未报告不良事件增加，表明在临床实践中具有良好的安全性。然而，需要进一步的高质量、大规模研究来证实这些结果。
