突变型和野生型黑腹果蝇中与年龄相关的α-甘油磷酸脱氢酶活性变化
Age-dependent alpha-glycerophosphate dehydrogenase activity changes in mutant and wild type Drosophila melanogaster.
作者信息
Baker G T
出版信息
Mech Ageing Dev. 1978 May;7(5):367-73. doi: 10.1016/0047-6374(78)90078-7.
The age-related changes in the activity of the extramitochondrial alpha-glycerophosphate dehydrogenase (alpha-GPDH) were compared in two mutants of Drosophila melanogaster, a vestigial-winged and an alpha-glycerophosphate dehydrogenase deficient mutant with that of the wild type. The age-dependent patterns of activity change in both mutants were shown to be identical to that of the wild type. This is in spite of the lack of flight ability in both mutants, the reduced enzyme activity levels in the alpha-glycerophosphate mutant, and in the case of the vestigial flies, of reduced life-span. The results suggest that those mechanisms responsible for the observed aged-related activity changes in alpha-GPDH are intrinsically regulated, independent of functional flight, genetic alteration of specific activity, and life-span.
在果蝇的两个突变体（一个是残翅突变体，另一个是α-甘油磷酸脱氢酶缺陷突变体）中，将线粒体外α-甘油磷酸脱氢酶（α-GPDH）活性的年龄相关变化与野生型进行了比较。结果表明，两个突变体中活性变化的年龄依赖性模式与野生型相同。尽管这两个突变体都缺乏飞行能力，α-甘油磷酸突变体中的酶活性水平降低，而对于残翅果蝇来说，其寿命缩短。这些结果表明，导致观察到的α-GPDH年龄相关活性变化的那些机制是内在调节的，与功能性飞行、比活性的遗传改变以及寿命无关。
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