Kumar A, Sharma H L, Sharma V N
Br J Pharmacol. 1976 Apr;56(4):491-3. doi: 10.1111/j.1476-5381.1976.tb07462.x.
The antiulcer and antisecretory activity of 2-chloro-10-[4'(N-beta-hydroxyethyl) piperazinyl-1'] acetylphenothiazine (SAS) has been investigated. At 10 and 20 mg/kg (s.c.) the drug was found to possess potent antigastric secretory and antiulcer activity (both in shay and stress ulcers) and did not exhibit any peripheral parasympathetic blocking activity. The pronounced antispasmodic activity of SAS was nonspecific rather than a specific parasympatholytic effect.
已对2-氯-10-[4'（N-β-羟乙基）哌嗪基-1']乙酰吩噻嗪（SAS）的抗溃疡和抗分泌活性进行了研究。皮下注射剂量为10和20mg/kg时，发现该药物具有强效的抗胃酸分泌和抗溃疡活性（对 Shay 溃疡和应激性溃疡均有效），且未表现出任何外周副交感神经阻滞活性。SAS 显著的解痉活性是非特异性的，而非特定的抗副交感神经效应。
