SAS（一种新型10-N-酰基氨基吩噻嗪）对大鼠胃分泌及溃疡形成的影响。
Effect of SAS (a new 10-N-acylaminophenothiazine) on gastric secretion and ulceration in rats.
作者信息
Kumar A, Sharma H L, Sharma V N
出版信息
Br J Pharmacol. 1976 Apr;56(4):491-3. doi: 10.1111/j.1476-5381.1976.tb07462.x.
Abstract
The antiulcer and antisecretory activity of 2-chloro-10-[4'(N-beta-hydroxyethyl) piperazinyl-1'] acetylphenothiazine (SAS) has been investigated. At 10 and 20 mg/kg (s.c.) the drug was found to possess potent antigastric secretory and antiulcer activity (both in shay and stress ulcers) and did not exhibit any peripheral parasympathetic blocking activity. The pronounced antispasmodic activity of SAS was nonspecific rather than a specific parasympatholytic effect.
摘要
已对2-氯-10-[4'（N-β-羟乙基）哌嗪基-1']乙酰吩噻嗪（SAS）的抗溃疡和抗分泌活性进行了研究。皮下注射剂量为10和20mg/kg时，发现该药物具有强效的抗胃酸分泌和抗溃疡活性（对 Shay 溃疡和应激性溃疡均有效），且未表现出任何外周副交感神经阻滞活性。SAS 显著的解痉活性是非特异性的，而非特定的抗副交感神经效应。
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本文引用的文献
1
PHARMACOLOGICAL RESEARCH ON GEFARNATE, A NEW SYNTHETIC ISOPRENOID WITH AN ANTI-ULCER ACTION.吉法酯的药理学研究，一种具有抗溃疡作用的新型合成类异戊二烯。
Arch Int Pharmacodyn Ther. 1964 Jan 1;147:113-45.
2
3
Pharmacologic actions of ethyl-methyl-isooctenyl amine (EMOA), a new parasympathetic ganglionic blocking agent.新型副交感神经节阻滞剂乙基-甲基-异辛烯胺（EMOA）的药理作用
J Pharmacol Exp Ther. 1956 Apr;116(4):377-86.
4
Synthesis and pharmacological action of 3-amino-2,1-benzisothiazoles.3-氨基-2,1-苯并异噻唑的合成与药理作用
J Med Chem. 1965 Jul;8(4):515-9. doi: 10.1021/jm00328a024.
5
Effect of aminoguanidine, chlorpromazine and NSD-1055 on gastric secretion and ulceration in the Shay rat.氨基胍、氯丙嗪和NSD - 1055对沙伊大鼠胃分泌及溃疡形成的影响
Br J Pharmacol. 1971 Jan;41(1):167-9. doi: 10.1111/j.1476-5381.1971.tb09946.x.
6
Phenothiazines as local anesthetics.吩噻嗪类作为局部麻醉剂。
J Med Chem. 1971 Jan;14(1):68-70. doi: 10.1021/jm00283a022.
7
Inhibition of food-stimulated gastrin release by a topical anesthetic, oxethazaine.一种局部麻醉剂奥昔卡因对食物刺激的胃泌素释放的抑制作用。
Am J Dig Dis. 1969 Nov;14(11):797-800. doi: 10.1007/BF02235969.
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